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Explanation/Disclaimer of Toxic Drug Concentrations

The data have been compiled from previously published scientific literature and from prior OCME experience; hence these concentrations cannot be regarded as complete for all therapeutic and poisoning situations. When available, references are included for a drug. Also, the appropriate screening assay [see Key] is designated for each drug. Average concentrations are given in parenthetical form when available. Many of the concentrations listed as toxic are from driving under the influence of drugs (DUID) data and are referenced as such in the comments column. The proper interpretation of postmortem drug concentrations is complex and complicated by many factors including individual variations in response to drugs, tolerance, physical stature, and disease states; the presence of other drugs, and the potential for postmortem changes in blood-drug concentrations. If a toxicological agent is suspected in a case, additional specimens, including peripheral blood (PB) and liver (LVR) should be submitted for a more complete investigation.

Assay Interpretation

A=Acids
B=Bases
N=Neutrals
E=Immunoassay
S=Special