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| Explanation/Disclaimer
of Toxic Drug Concentrations |
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The
data have been compiled from previously published scientific literature
and from prior OCME experience; hence these concentrations cannot
be regarded as complete for all therapeutic and poisoning situations.
When available, references are included for a drug. Also, the appropriate
screening assay [see Key] is designated for each drug. Average concentrations
are given in parenthetical form when available. Many of the concentrations
listed as toxic are from driving under the influence of drugs (DUID)
data and are referenced as such in the comments column. The proper
interpretation of postmortem drug concentrations is complex and
complicated by many factors including individual variations in response
to drugs, tolerance, physical stature, and disease states; the presence
of other drugs, and the potential for postmortem changes in blood-drug
concentrations. If a toxicological agent is suspected in a case,
additional specimens, including peripheral blood (PB) and liver
(LVR) should be submitted for a more complete investigation.
Assay
Interpretation
A=Acids
B=Bases
N=Neutrals
E=Immunoassay
S=Special
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